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Dosya:Penicillin inhibition.svg

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Şınasnayış
English: Diagram depicting formation of cross-links in the bacterial cell wall by a penicillin binding protein (PBP, an enzyme) and subsequent suicide inhibition by penicillin.

1. The bacterial cell wall consists of strands of repeating N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) subunits. The NAM subunits have short peptide chains attached to them. (The exact composition of these can vary. The proximal alanine is usually L-ala and the distal two are usually D-ala.)

2. The PBP binds the peptide side chains and forms the cross-link with the expulsion of one D-Alanine from one peptide side chain. (See PBP_catalysis.svg for details.)

3. The PBP dissociates from the wall once the cross-link has been formed.

4. Penicillin is added to the system. It enters the active site of the PBP and reacts with the serine group that is important in its enzymatic activity.

5. The beta-lactam ring of penicillin (represented here as the top of the "P") is irreversibly opened during the reaction with the PBP. Penicillin remains covalently linked to the PBP and permanently blocks the active site.
Italiano: Diagramma raffigurante la formazione di legami incrociati nella parete cellulare batterica da parte di una proteina legante la penicillina e inibizione suicidia della penicillina .

1. La parete cellulare batterica è costituito da filamenti di subunità ripetute N -acetil-glucosammina (NAG) e acido N-acetilmuramico (NAM). Le subunità NAM portano corte catene peptidiche attaccate. (La composizione esatta è variabile. L'alanina prossimale è solitamente una L-Ala e la due distali sono di solito D-Ala.)

2. La proteina lega le catene laterali peptidiche e forma la reticolazione con l'espulsione di una D-alanina da una catena laterale.

3. La proteina dissocia dalla parete una volta formato il reticolo.

4. Se penicillina viene aggiunto al sistema, essa entra nel sito attivo della proteina e reagisce con il gruppo serina il quale è importante per lattività enzimatica.

5. L'anello beta-lattamico della penicillina (qui rappresentato in rosso sulla "P") è irreversibilmente aperto durante la reazione con il proteina e rimanendo covalentemente ne blocca permanentemente il sito attivo.
Tarix
Çıme Karo şexsi
Nuştekar Mcstrother
Versiyonane binan

[bıvurne]

  • Cross-linking of bacteria cell wall with no antibiotics.
    Cross-linking of bacteria cell wall with no antibiotics.
  • Action of penicillin
    Action of penicillin
  • Resistance to penicillin via modified cross-linking enzyme.
    Resistance to penicillin via modified cross-linking enzyme.
  • Action of vancomycin and resistance via alteration of peptide side-chains.
    Action of vancomycin and resistance via alteration of peptide side-chains.
  • Spanish version.
    Spanish version.
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7 Adar 2011

Verêniya dosya

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Tarix/ZemanResımo qıckekEbadiKarberMışewre
nıkayên00:39, 10 Keşkelun 2011Seba versiyonê 00:39, 10 Keşkelun 2011 ra1,157 - 1,813 (1.34 MB)McstrotherCorrected errors in mechanism of cross-linking.
04:03, 3 Gulane 2011Seba versiyonê 04:03, 3 Gulane 2011 ra1,157 - 1,813 (1.09 MB)McstrotherChanged all fonts from "Sans" to "Liberation Sans" to fix overlap issues.
03:42, 10 Nisane 2011Seba versiyonê 03:42, 10 Nisane 2011 ra1,157 - 1,813 (1.09 MB)McstrotherChanged color of carbohydrate chain.
06:42, 7 Adare 2011Seba versiyonê 06:42, 7 Adare 2011 ra1,157 - 1,813 (1.08 MB)Mcstrother{{Information |Description ={{en|1=Diagram depicting formation of cross-links in the bacterial cell wall by a penicillin binding protein (PBP, an enzyme) and subsequent suicide inhibition by penicillin. 1. The bacterial cell wall consists of strands o

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